Veterinary Sciences, Free Full-Text
Por um escritor misterioso
Last updated 29 junho 2024
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Canine hemangiosarcoma (HSA) is a relatively common neoplasia, occurring mainly in the skin, spleen, liver and right atrium. Despite the numerous studies investigating the treatment of canine HSA, no significant improvement in survival has been achieved in the last 20 years. Advancements in genetic and molecular profiling presented molecular similarities between canine HSA and human angiosarcoma. It could therefore serve as a valuable model for investigating new and more effective treatments in people and dogs. The most common genetic abnormalities in canine HSA have been found in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and neuroblastoma RAS viral oncogene homolog (NRAS) pathways. Mutations are also found in tumor protein p53 (TP53), phosphatase and tensin homolog (PTEN) and cyclin dependent kinase inhibitor 2A (CDKN2A). Known abnormal protein expression could be exploited to trial new target treatments that could be beneficial for both canine and human patients. Despite the high expression of vascular endothelial growth factor (VEGF) and its receptor (VEGFR), no correlation with overall survival time has ever been found. In this review, we explore the most recent developments in molecular profiling in canine HSA and discuss their possible applications in the prognosis and treatment of this fatal disease.
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Veterinary Sciences An Open Access Journal from MDPI
Cypress Veterinary Clinic
Greenwich Veterinary Center
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A Text-book Of Animal Physiology, With Introductory Chapters On General Biology And A Full Treatment Of Reproduction, For Students Of Human And
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Additional Training - Animal Alternatives: Literature Searching for Animal Research: A Guide - Library Guides at Tulane University
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SAVMA's The Vet Gazette - Main
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Veterinary Terminology Chart - Clinical Charts and Supplies
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Detection of Brucella melitensis Using Real-time PCR and Isolation from Organs of Meat Goat in Thailand
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Veterinary Sciences, Free Full-Text
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FREE Taster Course for Veterinary Science by OET Online
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Dietary supplementation with free methionine or methionine dipeptide mitigates intestinal oxidative stress induced by Eimeria spp. challenge in broiler chickens, Journal of Animal Science and Biotechnology
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Veterinary Medicine: A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats 11th Edition PDF
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