Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond
Por um escritor misterioso
Last updated 30 junho 2024
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://www.jneurosci.org/content/jneuro/26/27/7151/F1.large.jpg)
Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://www.cell.com/cms/attachment/32886421-1398-4648-833d-55e029afde8c/gr3.jpg)
Remote Control of Gene Function by Local Translation: Cell
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://www.pnas.org/cms/10.1073/pnas.1010564107/asset/a1cc878f-bb44-4a41-aa55-1477be41dfc6/assets/graphic/pnas.1010564107fig05.jpeg)
Altered mRNA transport, docking, and protein translation in
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://royalsocietypublishing.org/cms/asset/74428704-d5ea-4d58-9345-1e10b3b9d79f/rsob200177f03.jpg)
Molecular mechanisms behind mRNA localization in axons
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://febs.onlinelibrary.wiley.com/cms/asset/33867c89-0bf8-4449-8090-1e06680d326b/febs15733-fig-0004-m.jpg)
Protein synthesis as a modifiable target for autism‐related
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://www.mdpi.com/ijms/ijms-23-06315/article_deploy/html/images/ijms-23-06315-g004.png)
IJMS, Free Full-Text
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://www.frontiersin.org/files/Articles/717170/fnmol-14-717170-HTML/image_m/fnmol-14-717170-g002.jpg)
Frontiers Local Translation Across Neural Development: A Focus
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://ars.els-cdn.com/content/image/3-s2.0-B978012800109700008X-f08-01-9780128001097.jpg)
FMRP and the Pathophysiology of Fragile X Syndrome - ScienceDirect
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://onlinelibrary.wiley.com/cms/asset/0e0cdbdb-f44f-49eb-ae0b-5a3e90b9a0f2/tra12004-toc-0001-m.jpg?trick=1699843066741)
mRNA Localization: An Orchestration of Assembly, Traffic and
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://www.frontiersin.org/files/Articles/323605/fnmol-10-00440-HTML/image_m/fnmol-10-00440-g001.jpg)
Frontiers Fragile X Mental Retardation Protein Regulates
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://journals.physiology.org/cms/10.1152/physrev.00047.2019/asset/images/medium/prv-00047-2019r01.png)
RNA-binding proteins balance brain function in health and disease
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41583-021-00445-9/MediaObjects/41583_2021_445_Fig1_HTML.png)
Channelopathies in fragile X syndrome
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://www.jneurosci.org/content/jneuro/30/17/5830/F5.large.jpg)
Synaptic Activity Controls Dendritic Spine Morphology by
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